From Wikipedia, the free encyclopedia
Content deleted Content added
|
 |
|||
| Line 1: | Line 1: | ||
|
[[image:Shearinine A,D,E,F.png|thumb|Shearinines A, D, E,and F]] |
[[image:Shearinine A,D,E,F.png|thumb|Shearinines A, D, E,and F]] |
||
|
”’Shearinines”’ A, D, E, and F, are marine fungal isolates with anticancer activity ”in vitro”. They were isolated from a stain of ”[[Penicillium janthinellum Biourge]]”. Their potential anticancer activity has been suggested by their induction of [[apoptosis]] in [[HL-60]] cells.<ref>{{cite journal | title=Indole alkaloids produced by a marine fungus isolate of Penicillium janthinellum Biourge |vauthors=Smetanina OF, etal | journal=J Nat Prod |date=Jun 2007 | volume=70 | issue=6 | pages=906–9 | doi=10.1021/np060396d | pmid=17555349|bibcode=2007JNAtP..70..906S }}</ref> Shearinines D, E and G have also been found to block activity on large-conductance [[calcium-activated potassium channel]]s.<ref>{{cite journal | title=Shearinines D–K, new indole triterpenoids from an endophytic Penicillium sp. (strain HKI0459) with blocking activity on large-conductance calcium-activated potassium channels | author=Xu, Minjuan| journal=Tetrahedron |date=Jan 2007 | volume=63 | issue=2 | pages=435–444 | doi=10.1016/j.tet.2006.10.050|display-authors=etal}}</ref> |
”’Shearinines”’ A, D, E, and F, are marine fungal isolates with anticancer activity ”in vitro”. They were isolated from a stain of ”[[Penicillium janthinellum Biourge]]”. Their potential anticancer activity has been suggested by their induction of [[apoptosis]] in [[HL-60]] cells.<ref>{{cite journal | title=Indole alkaloids produced by a marine fungus isolate of Penicillium janthinellum Biourge |vauthors=Smetanina OF, etal | journal=J Nat Prod |date=Jun 2007 | volume=70 | issue=6 | pages=906–9 | doi=10.1021/np060396d | pmid=17555349|bibcode=2007JNAtP..70..906S }}</ref> Shearinines D, E and G have also been found to block activity on large-conductance [[calcium-activated potassium channel]]s.<ref>{{cite journal | title=Shearinines D–K, new indole triterpenoids from an endophytic Penicillium sp. (strain HKI0459) with blocking activity on large-conductance calcium-activated potassium channels | author=Xu, Minjuan| journal=Tetrahedron |date=Jan 2007 | volume=63 | issue=2 | pages=435–444 | doi=10.1016/j.tet.2006.10.050|display-authors=etal}}</ref> |
||
| Line 7: | Line 7: | ||
|
[[Category:Indole alkaloids]] |
[[Category:Indole alkaloids]] |
||
|
{{alkaloid-stub}} |
{{alkaloid-stub}} |
||
Latest revision as of 23:22, 19 October 2025
Shearinines A, D, E, and F, are marine fungal isolates with anticancer activity in vitro. They were isolated from a stain of Penicillium janthinellum Biourge. Their potential anticancer activity has been suggested by their induction of apoptosis in HL-60 cells.[1] Shearinines D, E and G have also been found to block activity on large-conductance calcium-activated potassium channels.[2]
- ^ Smetanina OF, et al. (Jun 2007). “Indole alkaloids produced by a marine fungus isolate of Penicillium janthinellum Biourge”. J Nat Prod. 70 (6): 906–9. Bibcode:2007JNAtP..70..906S. doi:10.1021/np060396d. PMID 17555349.
- ^ Xu, Minjuan; et al. (Jan 2007). “Shearinines D–K, new indole triterpenoids from an endophytic Penicillium sp. (strain HKI0459) with blocking activity on large-conductance calcium-activated potassium channels”. Tetrahedron. 63 (2): 435–444. doi:10.1016/j.tet.2006.10.050.
