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”’Organ cryopreservation”’ |
”’Organ cryopreservation”’ [[cryopreservation]] of animals or human [[organs]], typically around -196 °C using [[liquid nitrogen]]. At this temperature, organs can be preserved for a long period, often more than a decade.<ref name=PubMed01>{{cite journal|url=https://pubmed.ncbi.nlm.nih.gov/37303729/|title=Cryopreservation of tissues and organs: present, bottlenecks, and future|journal=[[PubMed]]|first1=Jiangming|last1=Chen|first2=Xiangjian|last2=Liu|first3=Yuying|last3=Hu|first4=Xiaoxiao|last4=Chen|first5=Songwen|last5=Tan}}</ref> |
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As of |
As of2025, organ cryopreservation remains experimental.<ref>{{cite journal|url=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2025.1566080/full|title=Organ preservation: current limitations and optimization approaches|first1=Qiulin|last1=Ran|first2=Jiayi|last2=Zhang|first3=Jisheng|last3=Zhong|first4=Ji|last4=Lin|first5=Shuai|last5=Zhang|first6=Guang|last6=Li|first7=Bin|last7=You|journal=[[Frontiers in Medicine]]|date=26 March 2025}}</ref><ref name=PubMed02>{{cite journal|url=https://pubmed.ncbi.nlm.nih.gov/39456905/|title=Current State and Challenges of Tissue and Organ Cryopreservation in Biobanking|journal=[[PubMed]]|first1=Irina|last1=Khaydukova|first2=Valeria|last2=Ivannikova|first3=Dmitry|last3=Zhidkov|first4=Nikita|last4=Belikov|first5=Maria|last5=Peshkova|first6=Peter|last6=Timashev|first7=Dmitry|last7=Tsiganov|first8=Aleksandr|last8=Pushkarev}}</ref><ref name=PubMed03>{{cite journal|url=https://pmc.ncbi.nlm.nih.gov/articles/PMC2781091/|title=The cryopreservation of composite tissues|journal=[[PubMed]]|first1=Joseph|last1=Bakhach}}</ref>Most are usually preserved at temperature just above 0°C, which allows them to be stored for a few hours to a few days. Certain organs may be preserved at temperatures between -20°C to -50°C, enabling storage for a few weeks to a few months. In 2023, researchers successfully cryopreserved rat kidneys at -196°C using liquid nitrogen for 100 days.<ref name=PubMed04>{{cite journal|url=https://pubmed.ncbi.nlm.nih.gov/37296144/|title=Vitrification and nanowarming enable long-term organ cryopreservation and life-sustaining kidney transplantation in a rat model|journal=[[PubMed]]|first1=Zonghu|last1=Han|first2=Joseph|last2=Rao|first3=Lakshya|last3=Gangwar|first4=Bat|last4=Namsrai|first5=Jacqueline|last5=Allen|first6=Michael|last6=Etheridge|first7=Susan|last7=Wolf|first8=Timothy|last8=Pruett|first9=John|last9=Bischof|first10=Erik|last10=Finger}}</ref> |
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== See also == |
== See also == |
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Latest revision as of 08:43, 10 November 2025
Cryopreservation of Organs
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Organ cryopreservation is the cryopreservation of animals or human organs, typically around -196 °C using liquid nitrogen. At this temperature, organs can be preserved for a long period, often more than a decade.[1]
As of 2025[update], organ cryopreservation remains experimental.[2][3][4] Most organs are usually preserved at a temperature of just above 0°C, which allows them to be stored for a few hours to a few days. Certain organs may be preserved at temperatures between -20°C to -50°C, enabling storage for a few weeks to a few months. In 2023, researchers successfully cryopreserved rat kidneys at -196°C using liquid nitrogen for 100 days.[5]
- ^ Chen, Jiangming; Liu, Xiangjian; Hu, Yuying; Chen, Xiaoxiao; Tan, Songwen. “Cryopreservation of tissues and organs: present, bottlenecks, and future”. PubMed.
- ^ Ran, Qiulin; Zhang, Jiayi; Zhong, Jisheng; Lin, Ji; Zhang, Shuai; Li, Guang; You, Bin (26 March 2025). “Organ preservation: current limitations and optimization approaches”. Frontiers in Medicine.
- ^ Khaydukova, Irina; Ivannikova, Valeria; Zhidkov, Dmitry; Belikov, Nikita; Peshkova, Maria; Timashev, Peter; Tsiganov, Dmitry; Pushkarev, Aleksandr. “Current State and Challenges of Tissue and Organ Cryopreservation in Biobanking”. PubMed.
- ^ Bakhach, Joseph. “The cryopreservation of composite tissues”. PubMed.
- ^ Han, Zonghu; Rao, Joseph; Gangwar, Lakshya; Namsrai, Bat; Allen, Jacqueline; Etheridge, Michael; Wolf, Susan; Pruett, Timothy; Bischof, John; Finger, Erik. “Vitrification and nanowarming enable long-term organ cryopreservation and life-sustaining kidney transplantation in a rat model”. PubMed.
