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|date=2012|chapter-url=https://www.google.co.uk/books/edition/Flavonoids_and_Related_Compounds/30DNBQAAQBAJ?hl=en&gbpv=1&dq=Resveratrol+Japanese+knotweed&pg=PA171&printsec=frontcover|chapter=8 Occurence, Bioavailability and Metabolism of Resveratrol|title=Flavonoids and Related Compounds Bioavailability and Function|publisher=[[CRC Press]]|page=168, 171}}</ref>

|date=2012|chapter-url=https://www.google.co.uk/books/edition/Flavonoids_and_Related_Compounds/30DNBQAAQBAJ?hl=en&gbpv=1&dq=Resveratrol+Japanese+knotweed&pg=PA171&printsec=frontcover|chapter=8 Occurence, Bioavailability and Metabolism of Resveratrol|title=Flavonoids and Related Compounds Bioavailability and Function|publisher=[[CRC Press]]|page=168, 171}}</ref>

::[[trans-delta-viniferin|”trans”-delta-viniferin]] <ref name=PVetal/>

::[[trans-delta-viniferin|”trans”-delta-viniferin]] <ref name=PVetal/>

::”trans”-[[Piceatannol]] <ref name=PVetal/>

::”trans”-[[]] <ref name=PVetal/>

:[[Tannin]]s <ref name=Tijjani/>

:[[Tannin]]s <ref name=Tijjani/>

:[[Xanthones]] <ref>De-Jian Jiang, Zhong Dai, Yuan-Jian Li (7 June 2006) [https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1527-3466.2004.tb00133.x Pharmacological Effects of Xanthones as Cardiovascular Protective Agents] Cardiovascular Therapeutics 10.1111/j.1527-3466.2004.tb00133.x</ref>

:[[Xanthones]] <ref>De-Jian Jiang, Zhong Dai, Yuan-Jian Li (7 June 2006) [https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1527-3466.2004.tb00133.x Pharmacological Effects of Xanthones as Cardiovascular Protective Agents] Cardiovascular Therapeutics 10.1111/j.1527-3466.2004.tb00133.x</ref>


Latest revision as of 08:35, 23 November 2025

Polyphenols are a class of phytochemicals that have antioxidant properties [1][2] (modulate oxidative stress[3] have application as redox medecine [4]).

Sources of polyphenols

[edit]

Polyphenols are divided into numerous groups based on the strength of the phenolic ring. [5]

Primary classes and sources of different types of polyphenols: [6]

Curcuminoid curcuma longa rhizome [7]

bisdemethoxycurcumin [8]
curcumin [7]
demethoxycurcumin [7]
Flavonoid: [9][5][10]

Anthocyanins [6] aubergine, blackberry, black currant, blueberry, black grape, cherry, rhubarb [6]

apigenidin (AD) [11]
cyaniding (CY) [11]
delphinidin (D) [11]
malvidin (M) [11]
pelargonidin (PE) [11]
Flavanols apple, tea [11]

catechin (CA): [11] tea leaves, beans, black grapes, cherries, cacao [12]

epigallocatechin gallate / [8] epigallocatechin-3-gallate: green tea [13]
epicatechin (EC) [11][13]
epigallocatechin (EG) [11][13]
glausan-3 (G3) [11]
proanthocyanidins (P) [11]
Flavanones [6] orange juice, grapefruit juice, lemon juice [6]

eriodictyol [14]
hesperidin (H)) [11]
liquiritigenin [14]
naringenin (NE) [11]
naringin (NI) [11]
pinocembrin [14]
taxifolin (TA) [11]
Flavones [6] parsley, celery [6]

apigenin (A) [11]
chrysin (C) [11]
glucosidestangeretin (G) [11]
luteolin (L) [11]
rutin (R) [11]
Flavonols [6] yellow onion, curly kale, leek, cherry tomato, brocolli, blueberry [6]
Monomeric flavanols chocolate, beans, apricot [6]

kaempferol (K) [11]
myricetin (M) [11]
quercetin (Q) [11]
tamarixetin (T) [11]
Isoflavones [6] soy flour, boiled soybeans, miso, tofu, tempeh, soy milk [6]

daidzein (DA)) [11]
genistein (GE) [11]
Lignans [15][5][10]

lariciresinol [15]
matairesinol [15]
pinoresinol [15]
secoisolariciresinol diglucoside [15]
Phenolic acids:[15][5][10]

hydroxybenzoic acids: blackberry, raspberry, black currant [6]
hydroxycinnamic acids: blueberry, kiwi, cherry, plum [6]
Phenylethanoid glucosides [16]

verbascoside: olive [17]
Secoiridoid [17]

oleuropein: olive [18][17]
Stilbenes [15][5][10]

pallidol [19]
resveratrol:[15] japanese knotweed [19]
trans-delta-viniferin [19]
transpiceatannol [19]
Tannins [10]
Xanthones [20]

bis-xanthones [21]
prenylated xanthone [21]
simple xanthones [21]
xanthone glucosides / glycosylated xanthones [21]

mangiferin mangifera indica [8][22]
xanthonolignoids [21]
  1. ^ Qiushi Huang; et al. (November 2020). “Dietary Polyphenol Intake in US Adults and 10-Year Trends: 2007-2016”. Journal of the Academy of Nutrition and Dietetics. 120 (11).
  2. ^ Kanti Bhooshan Pandey; Syed Ibrahim Rizvi (Nov–Dec 2009). “Plant polyphenols as dietary antioxidants in human health and disease”. Oxidative Medicine and Cellular Longevity. 2 (5). University of Allahabad. doi:10.4161/oxim.2.5.9498. PMID 20716914.{{cite journal}}: CS1 maint: date format (link)
  3. ^ Scalbert, Augustin; Johnson, Ian; Saltmarsh, Mike (January 2005). “Polyphenols: antioxidants and beyond”. The American Journal of Clinical Nutrition. 81 (1). doi:10.1093/ajcn/81.1.215S.
  4. ^ Helmut Sies; Carsten Berndt; Dean P. Jones (2017). “Oxidative Stress – Approaches Decreasing Oxidative Stress (Therapeutic Antioxidants): Figure 12”. Annu. Rev. Biochem. 86. doi:10.1146/annurev-biochem-061516-045037.
  5. ^ a b c d e Abrar Ahmad, Varish Ahmad, Mazin A. Zamzami, Hani Chaudhary, Othman A. Baothman, Salman Hosawi, Mohammad Kashif, Mohammad Salman Akhtar, Mohd Jahir Khan “Introduction and Classification of Natural Polyphenols”. Polyphenols-based Nanotherapeutics for Cancer Management. Springer, Singapore. 2 October 2021. doi:10.1007/978-981-16-4935-6_1. ISBN 978-981-16-4935-6. phenolic acids, flavonoids, stiblins (a type of polyphenol), phenolic alcohols, and lignans being the most common
  6. ^ a b c d e f g h i j k l m n Hasna El Gharras. Charles Brennan (ed.). “Polyphenols: food sources, properties and applications”. International Journal of Food Science and Technology. 44 (12). doi:10.1111/j.1365-2621.2009.02077.x.
  7. ^ a b c Panchanan Maiti; Gary L Dunbar (31 May 2018). “Use of Curcumin, a Natural Polyphenol for Targeting Molecular Pathways in Treating Age-Related Neurodegenerative Diseases”. Int J Mol Sci. 19 (6). doi:10.3390/ijms19061637.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  8. ^ a b c Maroua Jalouli; Md Ataur Rahman; Partha Biswas; Hasanur Rahman; Abdel Halim Harrath; In-Seon Lee; Sojin Kang; Jinwon Choi; Moon Nyeo Park; Bonglee Kim (24 January 2025). “Targeting natural antioxidant polyphenols to protect neuroinflammation and neurodegenerative diseases: a comprehensive review”. Front Pharmacol. 16 (1492517). doi:10.3389/fphar.2025.1492517.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  9. ^ Alberto Bertelli, Marco Biagi, Maddalena Corsini, Giulia Baini, Giorgio Cappellucci, Elisabetta Miraldi Polyphenols: From Theory to Practice Foods 2021, 10(11) 10.3390/foods10112595
  10. ^ a b c d e Habibu Tijjani, Maryam H. Zangoma, Zinat S. Mohammed, Shakirdeen M. Obidola, Chukwuebuka Egbuna & Suliat I. Abdulai 25 August 2020 Functional Foods and Nutraceuticals
    Polyphenols: Classifications, Biosynthesis and Bioactivities 10.1007/978-3-030-42319-3_19 Springer, Cham ISBN 978-3-030-42319-3
  11. ^ a b c d e f g h i j k l m n o p q r s t u v w x y z Prithviraj Karak BIOLOGICAL ACTIVITIES OF FLAVONOIDS: AN OVERVIEW IJPSR, 2019; Vol. 10(4):
  12. ^ Jong Min Kim; Ho Jin Heo (2022). “The roles of catechins in regulation of systemic inflammation”. Food Sci Biotechnol. 31. Korean Society of Food Science and Technology: Springer Nature. doi:10.1007/s10068-022-01069-0.
  13. ^ a b c Siying Li; Zaoyi Wang; Gang Liu; Meixia Chen (1 August 2024). “Neurodegenerative diseases and catechins: (−)-epigallocatechin-3-gallate is a modulator of chronic neuroinflammation and oxidative stress”. Front. Nutr. 11. doi:10.3389/fnut.2024.1425839.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  14. ^ a b c Mireia Urpa-Sarda; Joseph Rothwell; Christine Morand; Claudine Manach (2012). “Bioavailability of Flavanones”. In Alan Crozier; Jeremy P. E. Spencer (eds.). Flavonoids and Related Compounds Bioavailability and Function. CRC Press. p. 2.
  15. ^ a b c d e f g h Daria Ciupei, Alexandru Colişar, Loredana Leopold, Andreea Stănilă, Zorița M Diaconeasa Polyphenols: From Classification to Therapeutic Potential and Bioavailability Foods. 2024 Dec 20;13(24):4131. doi: 10.3390/foods13244131
  16. ^ Mirjana Marčetić; Biljana Bufan; Milica Drobac; Jelena Antić Stanković; Nevena Arsenović Ranin; Marina T Milenković; Dragana D Božić (11 July 2025). “Multifaceted Biological Properties of Verbascoside/Acteoside: Antimicrobial, Cytotoxic, Anti-Inflammatory, and Immunomodulatory Effects”. Antibiotics (Basel). 14 (7).
  17. ^ a b c Syed Haris Omar (23 April 2010). “Oleuropein in Olive and its Pharmacological Effects – 3. Chemistry, biosynthesis and fate of oleuropein 3.1. Chemistry”. Sci Pharm. 78 (2). Qassim University. doi:10.3797/scipharm.0912-18. PMID 21179340.
  18. ^ Barbara Barbaro; Gabriele Toietta; Roberta Maggio; Mario Arciello; Mirko Tarocchi; Andrea Galli; Clara Balsano (14 October 2014). “Effects of the Olive-Derived Polyphenol Oleuropein on Human Health – 2. Effects of Oleuropein on Human Health 2.1. Antioxidant Effect”. Int J Mol Sci. 15 (10). Visioli et al. demonstrated in healthy volunteers that administration of oleuropein decreases, in a dose-dependent manner, the urinary excretion of 8-iso-PGF2α, indicating lower in vivo lipid peroxidation [34]. A scavenging effect of oleuropein was also demonstrated with respect to hypochlorous acid [30], a potent oxidant species produced in vivo by neutrophils myeloperoxidase at the site of inflammation [35].
  19. ^ a b c d Paola Vitaglione; Stefano Sforza; Daniele Del Rio (2012). “8 Occurence, Bioavailability and Metabolism of Resveratrol”. In Alan Crozier; Jeremy P. E. Spencer (eds.). Flavonoids and Related Compounds Bioavailability and Function. CRC Press. p. 168, 171.
  20. ^ De-Jian Jiang, Zhong Dai, Yuan-Jian Li (7 June 2006) Pharmacological Effects of Xanthones as Cardiovascular Protective Agents Cardiovascular Therapeutics 10.1111/j.1527-3466.2004.tb00133.x
  21. ^ a b c d e Qing Huang; Youyi Wang; Huaimo Wu; Man Yuan; Changwu Zheng; Hongxi Xu (14 September 2021). “Xanthone Glucosides: Isolation, Bioactivity and Synthesis”. Molecules. 26 (18:5575). doi:10.3390/molecules26185575.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  22. ^ Aya M Mustafa; Ghadir A Bastawesy; Shymaa Hatem; Roxane Abdel-Gawad Moussa; Dina M Hal; Mariam H Fawzy; Mahmoud A Mansour; Mohamed S Abd El Hafeez (22 July 2025). “Polyphenolic protection: the role of mangiferin in mitigating neurodegeneration and neuroinflammation”. Inflammopharmacology. 33 (8 :4535–4552.). doi:10.1007/s10787-025-01854-3.
  23. ^ a b Ming Hu, Baojian Wu, Zhongqiu Liu Bioavailability of Polyphenols and Flavonoids in the Era of Precision Medicine Molecular PharmaceuticsVol 14/Issue 9

Alfonso Pompella, Helmut Sies, Roland Wacker, Fred Brouns, Tilman Grune, Hans Konrad Biesalski, Jan Frank The use of total antioxidant capacity as surrogate marker for food quality and its effect on health is to be discouraged Nutrition Volume 30, Issues 7–8, July–August 2014 “Many phytochemicals, for example, are poorly absorbed and rapidly metabolized into molecules with altered physicochemical, and therefore biological, properties. Consequently, the use of TAC assays for the in vitro assessment of antioxidant quality of food, which often is employed as a marketing argument or for the assessment of the “wholesomeness” of food, is to be discouraged…Other antioxidant food components, including flavonoids, phenolic acids, and other phytochemicals, however, may not act as antioxidants within the organism, because they undergo extensive first-pass metabolism in the intestine and liver during which redox-active hydroxyl groups are conjugated with functional groups (e.g., glucuronic acids, sulfate, methyl substituents), which abolishes their antioxidant function. In addition and in contrast with ascorbic acid and α-tocopherol, which are absorbed well, the uptake of plant polyphenols is limited and only a few percent of the ingested dose is typically taken up into the body”

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