[[Endothelin receptor antagonist|Endothelin-1 receptor antagonist]]s ([[Bosentan]]) are used in the treatment of [[pulmonary hypertension]].<ref name=dav/> Use of these antagonists prevents pulmonary arterial constriction and thus inhibits pulmonary hypertension.<ref name=dav/>
[[Endothelin receptor antagonist|Endothelin-1 receptor antagonist]]s ([[Bosentan]]) are used in the treatment of [[pulmonary hypertension]].<ref name=dav/> Use of these antagonists prevents pulmonary arterial constriction and thus inhibits pulmonary hypertension.<ref name=dav/>
As of 2020, the role of endothelin-1 in affecting [[lipid metabolism]] and [[insulin resistance]] in [[obesity]] mechanisms was under [[clinical research]].<ref name=”jenkins”>{{cite journal | vauthors = Jenkins HN, Rivera-Gonzalez O, Gibert Y, Speed JS | title = Endothelin-1 in the pathophysiology of obesity and insulin resistance | journal = Obesity Reviews | volume = 21 | issue = 12 | pages = e13086 | date = December 2020 | pmid = 32627269 | pmc = 7669671 | doi = 10.1111/obr.13086 }}</ref>
As of 2020, the role of endothelin-1 in affecting [[lipid metabolism]] and [[insulin resistance]] in [[obesity]] mechanisms was under [[clinical research]].<ref name=”jenkins”>{{cite journal | vauthors = Jenkins HN, Rivera-Gonzalez O, Gibert Y, Speed JS | title = Endothelin-1 in the pathophysiology of obesity and insulin resistance | journal = Obesity Reviews | volume = 21 | issue = 12 | = e13086 | date = December 2020 | pmid = 32627269 | pmc = 7669671 | doi = 10.1111/obr.13086 }}</ref>
== References ==
== References ==
Vasoconstricting peptide
Endothelin 1 (ET-1), also known as preproendothelin-1 (PPET1), is the most potent vasoconstrictor produced by the human body.[5] It is a peptide produced by vascular endothelial cells,[6] as well as by cells in the heart (affecting contractility) and kidney (affecting sodium handling).[7] The protein encoded by this gene – EDN1 – is proteolytically processed to release endothelin 1. Endothelin 1 is one of three isoforms of human endothelin.
Preproendothelin is precursor of the peptide ET-1. Endothelial cells convert preproendothelin to proendothelin and subsequently to mature endothelin, which the cells release.[6][8]
Clinical significance
[edit]
Patients with salt-sensitive hypertension have higher plasma ET-1.[7]
Endothelin-1 receptor antagonists (Bosentan) are used in the treatment of pulmonary hypertension.[6] Use of these antagonists prevents pulmonary arterial constriction and thus inhibits pulmonary hypertension.[6]
As of 2020, the role of endothelin-1 in affecting lipid metabolism and insulin resistance in obesity mechanisms was under clinical research.[9]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000078401 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021367 – Ensembl, May 2017
- ^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Dhaun, Neeraj; Webb, David J. (August 2019). “Endothelins in cardiovascular biology and therapeutics”. Nature Reviews Cardiology. 16 (8): 491–502. doi:10.1038/s41569-019-0176-3. ISSN 1759-5010.
- ^ a b c d Davenport AP, Hyndman KA, Dhaun N, Southan C, Kohan DE, Pollock JS, et al. (April 2016). “Endothelin”. Pharmacological Reviews. 68 (2): 357–418. doi:10.1124/pr.115.011833. PMC 4815360. PMID 26956245.
- ^ a b Jankowich M, Choudhary G (2020). “Endothelin-1 levels and cardiovascular events”. Trends in Cardiovascular Medicine. 30 (1): 1–8. doi:10.1016/j.tcm.2019.01.007. PMID 30765295.
- ^ Boulpaep EL, Boron WF (2009). Medical physiology: a cellular and molecular approach. Saunders/Elsevier. ISBN 978-1-4160-3115-4.
- ^ Jenkins HN, Rivera-Gonzalez O, Gibert Y, Speed JS (December 2020). “Endothelin-1 in the pathophysiology of obesity and insulin resistance”. Obesity Reviews. 21 (12) e13086. doi:10.1111/obr.13086. PMC 7669671. PMID 32627269.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
