In [[enzymology]], a ”’methylmalonyl-CoA carboxytransferase”’ ({{EC number|2.1.3.1}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]
In [[enzymology]], a ”’methylmalonyl-CoA carboxytransferase”’ ({{EC number|2.1.3.1}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]
{{Chemrxn|width=70%|
:(S)-methylmalonyl-CoA + pyruvate <math>\rightleftharpoons</math> propanoyl-CoA + oxaloacetate
{{Chemrxn/cpd|pyruvic acid}}
{{Chemrxn/arw|direction=reversible|fwd_in=(S)-methylmalonyl-CoA|fwd_out=propanoyl-CoA}}
{{Chemrxn/cpd|oxaloacetic acid}}
}}
Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[(S)-methylmalonyl-CoA]] and [[pyruvate]], whereas its two [[product (chemistry)|products]] are [[propanoyl-CoA]] and [[oxaloacetate]].
This enzyme belongs to the family of [[transferase]]s that transfer one-carbon groups, specifically the carboxy- and carbamoyltransferases. The [[List of enzymes|systematic name]] of this enzyme class is ”'(S)-methylmalonyl-CoA:pyruvate carboxytransferase”’. Other names in common use include ”’transcarboxylase”’, ”’methylmalonyl coenzyme A carboxyltransferase”’, ”’methylmalonyl-CoA transcarboxylase”’, ”’oxalacetic transcarboxylase”’, ”’methylmalonyl-CoA carboxyltransferase”’, ”’methylmalonyl-CoA carboxyltransferase”’, ”'(S)-2-methyl-3-oxopropanoyl-CoA:pyruvate carboxyltransferase”’, ”'(S)-2-methyl-3-oxopropanoyl-CoA:pyruvate carboxytransferase”’, and ”’carboxytransferase [incorrect]”’. This enzyme participates in [[propanoate metabolism]]. It has 3 [[cofactor (biochemistry)|cofactors]]: [[zinc]], [[Biotin]], and [[Cobalt]].
This enzyme belongs to the family of [[transferase]]s that transfer one-carbon groups, specifically the carboxy- and carbamoyltransferases. The [[List of enzymes|systematic name]] of this enzyme class is ”'(S)-methylmalonyl-CoA:pyruvate carboxytransferase”’. Other names in common use include ”’transcarboxylase”’, ”’methylmalonyl coenzyme A carboxyltransferase”’, ”’methylmalonyl-CoA transcarboxylase”’, ”’oxalacetic transcarboxylase”’, ”’methylmalonyl-CoA carboxyltransferase”’, ”’methylmalonyl-CoA carboxyltransferase”’, ”'(S)-2-methyl-3-oxopropanoyl-CoA:pyruvate carboxyltransferase”’, ”'(S)-2-methyl-3-oxopropanoyl-CoA:pyruvate carboxytransferase”’, and ”’carboxytransferase [incorrect]”’. This enzyme participates in [[propanoate metabolism]]. It has 3 [[cofactor (biochemistry)|cofactors]]: [[zinc]], [[Biotin]], and [[Cobalt]].
==References==
==References==
{{Reflist}}
{{Reflist}}
* {{cite journal |author1 = Swick RW |author2 =Wood HG | year = 1960 | title = The role of transcarboxylation in propionic acid fermentation | journal = Proc. Natl. Acad. Sci. USA | volume = 46 | issue = 1 | pages = 28–41 | doi = 10.1073/pnas.46.1.28 | pmc = 285006 | pmid=16590594|bibcode =1960PNAS…46…28S |doi-access =free }}
{{One carbon transferases}}
{{One carbon transferases}}
Class of enzymes
In enzymology, a methylmalonyl-CoA carboxytransferase (EC 2.1.3.1) is an enzyme that catalyzes the chemical reaction
Â
(S)-methylmalonyl-CoA
propanoyl-CoA
Â
The enzyme can convert and pyruvate to oxaloacetate, using (S)-methylmalonyl-CoA as its cofactor.[1][2][3]
This enzyme belongs to the family of transferases that transfer one-carbon groups, specifically the carboxy- and carbamoyltransferases. The systematic name of this enzyme class is (S)-methylmalonyl-CoA:pyruvate carboxytransferase. Other names in common use include transcarboxylase, methylmalonyl coenzyme A carboxyltransferase, methylmalonyl-CoA transcarboxylase, oxalacetic transcarboxylase, methylmalonyl-CoA carboxyltransferase, methylmalonyl-CoA carboxyltransferase, (S)-2-methyl-3-oxopropanoyl-CoA:pyruvate carboxyltransferase, (S)-2-methyl-3-oxopropanoyl-CoA:pyruvate carboxytransferase, and carboxytransferase [incorrect]. This enzyme participates in propanoate metabolism. It has 3 cofactors: zinc, Biotin, and Cobalt.
Structural studies
As of late 2007, 12 structures have been solved for this class of enzymes, with PDB accession codes 1DCZ, 1DD2, 1ON3, 1ON9, 1RQB, 1RQE, 1RQH, 1RR2, 1S3H, 1U5J, 2D5D, and 2EVB.
