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Dimethylation of arginine in proteins is mediated by various [[enzyme]]s, including [[protein arginine methyltransferase 5]]<ref>{{cite journal |last1= Stopa |first1= Nicole |last2= Krebs |first2= Jocelyn E. |last3= Shechter |first3= David |title= The PRMT5 arginine methyltransferase: Many roles in development, cancer and beyond |journal= Cellular and Molecular Life Sciences |date= 2015 |volume= 72 |issue= 11 |pages= 2041–2059 |doi= 10.1007/s00018-015-1847-9 |pmid= 25662273 |pmc= 4430368 }}</ref> as part of a regulatory pathway of [[transcription (biology)|transcription]]. |
Dimethylation of arginine in proteins is mediated by various [[enzyme]]s, including [[protein arginine methyltransferase 5]]<ref>{{cite journal |last1= Stopa |first1= Nicole |last2= Krebs |first2= Jocelyn E. |last3= Shechter |first3= David |title= The PRMT5 arginine methyltransferase: Many roles in development, cancer and beyond |journal= Cellular and Molecular Life Sciences |date= 2015 |volume= 72 |issue= 11 |pages= 2041–2059 |doi= 10.1007/s00018-015-1847-9 |pmid= 25662273 |pmc= 4430368 }}</ref> as part of a regulatory pathway of [[transcription (biology)|transcription]]. |
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SDMA has been explored as a possible [[biomarker]] for [[kidney]] disease in cats<ref>{{cite journal |last1= Paltrinieri |first1= Saverio |last2= Giraldi |first2= Marco |last3= Prolo |first3= Amanda |last4= Scarpa |first4= Paola |last5= Piseddu |first5= Eleonora |last6= Beccati |first6= Massimo |last7= Graziani |first7= Benedetta |last8= Bo |first8= Stefano |title= Serum symmetric dimethylarginine and creatinine in Birman cats compared with cats of other breeds |journal= Journal of Feline Medicine and Surgery |date= 2018 |volume= 20 |issue= 10 |pages= 905–912 |doi= 10.1177/1098612X17734066 |pmid= 28994640 |pmc= 11129243 }}</ref><ref>{{cite journal |last1= Braff |first1= J. |last2= Obare |first2= E. |last3= Yerramilli |first3= M. |last4= Elliott |first4= J. |last5= Yerramilli |first5= M. |title= Relationship between Serum Symmetric Dimethylarginine Concentration and Glomerular Filtration Rate in Cats |journal= Journal of Veterinary Internal Medicine |date= 2014 |volume= 28 |issue= 6 |pages= 1699–1701 |doi= 10.1111/jvim.12446 |pmid= 25272985 |pmc= 4895615 }}</ref> and dogs.<ref> |
SDMA has been explored as a possible [[biomarker]] for [[kidney]] disease in cats<ref>{{cite journal |last1= Paltrinieri |first1= Saverio |last2= Giraldi |first2= Marco |last3= Prolo |first3= Amanda |last4= Scarpa |first4= Paola |last5= Piseddu |first5= Eleonora |last6= Beccati |first6= Massimo |last7= Graziani |first7= Benedetta |last8= Bo |first8= Stefano |title= Serum symmetric dimethylarginine and creatinine in Birman cats compared with cats of other breeds |journal= Journal of Feline Medicine and Surgery |date= 2018 |volume= 20 |issue= 10 |pages= 905–912 |doi= 10.1177/1098612X17734066 |pmid= 28994640 |pmc= 11129243 }}</ref><ref>{{cite journal |last1= Braff |first1= J. |last2= Obare |first2= E. |last3= Yerramilli |first3= M. |last4= Elliott |first4= J. |last5= Yerramilli |first5= M. |title= Relationship between Serum Symmetric Dimethylarginine Concentration and Glomerular Filtration Rate in Cats |journal= Journal of Veterinary Internal Medicine |date= 2014 |volume= 28 |issue= 6 |pages= 1699–1701 |doi= 10.1111/jvim.12446 |pmid= 25272985 |pmc= 4895615 }}</ref> and dogs.<ref>{{cite journal |last1= Nabity |first1= M.B. |last2= Lees |first2= G.E. |last3= Boggess |first3= M.M. |last4= Yerramilli |first4= M. |last5= Obare |first5= E. |last6= Yerramilli |first6= M. |last7= Rakitin |first7= A. |last8= Aguiar |first8= J. |last9= Relford |first9= R. |title= Symmetric Dimethylarginine Assay Validation, Stability, and Evaluation as a Marker for the Early Detection of Chronic Kidney Disease in Dogs |journal= Journal of Veterinary Internal Medicine |date= 2015 |volume= 29 |issue= 4 |pages= 1036–1044 |doi= 10.1111/jvim.12835 |pmid= 26079532 |pmc= 4895368 }}</ref> |
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== References == |
== References == |
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Latest revision as of 11:03, 20 December 2025
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Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Chemical compound
Symmetric dimethylarginine (SDMA) is produced during catabolism of proteins. It consists of an arginine core, with one methyl group on each of the two terminal side-chain nitrogen atoms.
Dimethylation of arginine in proteins is mediated by various enzymes, including protein arginine methyltransferase 5[1] as part of a regulatory pathway of transcription.
SDMA has been explored as a possible biomarker for kidney disease in cats[2][3] and dogs.[4]
- ^ Stopa, Nicole; Krebs, Jocelyn E.; Shechter, David (2015). “The PRMT5 arginine methyltransferase: Many roles in development, cancer and beyond”. Cellular and Molecular Life Sciences. 72 (11): 2041–2059. doi:10.1007/s00018-015-1847-9. PMC 4430368. PMID 25662273.
- ^ Paltrinieri, Saverio; Giraldi, Marco; Prolo, Amanda; Scarpa, Paola; Piseddu, Eleonora; Beccati, Massimo; Graziani, Benedetta; Bo, Stefano (2018). “Serum symmetric dimethylarginine and creatinine in Birman cats compared with cats of other breeds”. Journal of Feline Medicine and Surgery. 20 (10): 905–912. doi:10.1177/1098612X17734066. PMC 11129243. PMID 28994640.
- ^ Braff, J.; Obare, E.; Yerramilli, M.; Elliott, J.; Yerramilli, M. (2014). “Relationship between Serum Symmetric Dimethylarginine Concentration and Glomerular Filtration Rate in Cats”. Journal of Veterinary Internal Medicine. 28 (6): 1699–1701. doi:10.1111/jvim.12446. PMC 4895615. PMID 25272985.
- ^ Nabity, M.B.; Lees, G.E.; Boggess, M.M.; Yerramilli, M.; Obare, E.; Yerramilli, M.; Rakitin, A.; Aguiar, J.; Relford, R. (2015). “Symmetric Dimethylarginine Assay Validation, Stability, and Evaluation as a Marker for the Early Detection of Chronic Kidney Disease in Dogs”. Journal of Veterinary Internal Medicine. 29 (4): 1036–1044. doi:10.1111/jvim.12835. PMC 4895368. PMID 26079532.
