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{{AFC submission|d|nn|u=AndGG97|ns=2|decliner=Theroadislong|declinets=20251202104029|ts=20251202102911}} <!– Do not remove this line! –> |
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{{AFC comment|1=If “Epigenetic clock” is the title of the draft it should be in the first line. [[User:Theroadislong|Theroadislong]] ([[User talk:Theroadislong|talk]]) 10:47, 2 December 2025 (UTC)}} |
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{{Short description|Addition to Epigenetic Clock Wiki page, Relationship to a cause of biological aging section}} |
{{Short description|Addition to Epigenetic Clock Wiki page, Relationship to a cause of biological aging section}} |
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==DNA methylation and aging== |
==DNA methylation and aging== |
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A 2025 study used CRISPR-based epigenetic editing to alter DNA methylation at selected age-associated [[CpG sites]] (including loci in [[PDE4C]] and [[FHL2]]), reporting methylation changes at many additional, genomically distant CpGs. |
A 2025 study used CRISPR-based epigenetic editing to alter DNA methylation at selected age-associated [[CpG sites]] (including loci in [[PDE4C]] and [[FHL2]]), reporting methylation changes at many additional, genomically distant CpGs.<ref>{{cite journal |last1=Liesenfelder |first1=Sven |title=Epigenetic editing at individual age-associated CpGs affects the genome-wide epigenetic aging landscape |journal=Nature Aging |date=24 March 2025 |doi=10.1038/s43587-025-00841-1 |url=https://www.nature.com/articles/s43587-025-00841-1}}</ref> A 2022 review noted that age-related methylation differences may occur in a coordinated “co-methylation” module, consistent with chromatin-level regulation rather than isolated CpGs. <ref>{{cite journal |last1=Seale |first1=Kirsten |title=Making sense of the ageing methylome |journal=Nat Rev Genet |date=02 May 2022 |issue=October 22 |doi=https://doi.org/10.1038/s41576-022-00477-6 |url=https://www.nature.com/articles/s41576-022-00477-6#citeas}}</ref> In the 2025 study, the authors proposed that distant effects could be influenced by three-dimensional [[chromatin]] organization.<ref>{{cite journal |last1=Liesenfelder |first1=Sven |title=Epigenetic editing at individual age-associated CpGs affects the genome-wide epigenetic aging landscape |journal=Nature Aging |date=24 March 2025 |doi=10.1038/s43587-025-00841-1 |url=https://www.nature.com/articles/s43587-025-00841-1}}</ref> |
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Latest revision as of 10:47, 2 December 2025
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Comment: If “Epigenetic clock” is the title of the draft it should be in the first line. Theroadislong (talk) 10:47, 2 December 2025 (UTC)
Addition to Epigenetic Clock Wiki page, Relationship to a cause of biological aging section
Relationship to a cause of biological aging
[edit]
Ageing is associated with genome-wide changes in DNA methylation at CpG sites, marks that support epigenetic clocks. It has been suggested that these methylation patterns do not occur in isolation. A 2022 review describes coordinated “co-methylation” modules in which CpGs change together with age, suggesting a chromatin-level regulation rather than individual sites by themselves.[1]
A study, published in 2025, used CRISPR-based epigenetic editing techniques to modify DNA methylation at age-associated CpG sites, including PDE4C and FHL2 genes. The authors report that modifying methylation at selected loci was followed by methylation changes at genomically distant CpGs. They propose that this modification may be mediated by chromatin folding that brings distal regulatory regions physically closer.[2]
DNA methylation and aging
[edit]
A 2025 study used CRISPR-based epigenetic editing to alter DNA methylation at selected age-associated CpG sites (including loci in PDE4C and FHL2), reporting methylation changes at many additional, genomically distant CpGs.[3] A 2022 review noted that age-related methylation differences may occur in a coordinated “co-methylation” module, consistent with chromatin-level regulation rather than isolated CpGs. [4] In the 2025 study, the authors proposed that distant effects could be influenced by three-dimensional chromatin organization.[5]
