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This user understands the science behind climate change and makes efforts to mitigate the problem. |
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Expertise
Science (general), genetics, molecular biology, medical genetics, biochemistry, toxicology, immunology, marine biology, ecology, scientific writing/editing, healthcare policy, environmental policy.
Other interests
Languages, etymology, linguistics, music history, women’s history.
WikiProjects
active participant
– Category: List of Women’s Firsts
– Category: Women
interested
Links
Categorization
Cleanup
Guides
Currently Editing⬇️
To remind myself why I just logged on here in the first place. : )
Epigenetic clock
“Under construction message box;
“Under construction”
Epigenetic clock. Find open-access infographic explaining. More citations, cleanup informal language, move biographical text (move to corresponding biographical article), update with new developments in field, reorganize headings to facilitate future expansion of article (easy to update with new developments).
1st gen clocks (notable):
- Horvath’s Clock (2013),
- Hannum’s Clock (2013),
- Other 1st gen clocks:
Bocklandt (2011),
Skin & Blood Clock (Horvath 2018)
Belsky 2015?
Second-generation epigenetic clocks (notable):
- PhenoAge (Levine, 2018),
- GrimAge (Lu,2019),
- GrimAge-v2 (AgeAccelGrim),
- DunedinPoAm.?
Third generation:
Belsky measures the pace of epigenetic aging rather than a static age in DunedinPACE
Other approaches:
Causality-enriched clocks: CausAge, AdaptAge, and DamAge
Neural network-based models (e.g., DeepMAge, AltumAge)
Ancestry cohorts (iCAS-DNAmAge =Chinese populations)
Refs
Epigenetic clock: A promising biomarker and practical tool in aging https://pubmed.ncbi.nlm.nih.gov/36206857/ (https://www.sciencedirect.com/science/article/abs/pii/S1568163722001854)
The use of DNA methylation clock in aging research https://pmc.ncbi.nlm.nih.gov/articles/PMC7885055/
What Are Epigenetic Clocks and Their Role in Aging Research https://federalhealthgroup.com/posts/what-are-epigenetic-clocks-and-their-role-in-aging-research/
An epigenetic biomarker of aging for lifespan and healthspan (Levine et al, 2018) https://pubmed.ncbi.nlm.nih.gov/29676998/
Using Epigenetic Clocks to Characterize Biological Aging in Studies of Children and Childhood Exposures: a Systematic Review https://pmc.ncbi.nlm.nih.gov/articles/PMC10964791/#R53
Epigenetic clocks and programmatic aging
Exploring the correlation between DNA methylation and biological age using an interpretable machine learning framework https://www.sciencedirect.com/science/article/pii/S1568163724003647
A systematic review of phenotypic and epigenetic clocks used for aging and mortality quantification in humans https://pmc.ncbi.nlm.nih.gov/articles/PMC11424583/
See Table 1, “Table 1. Descriptive statistics of all included first-generation epigenetic clocks.” — Big table listing several clocks)
Comprehensive analysis of epigenetic clocks reveals associations between disproportionate biological ageing and hippocampal volume https://pmc.ncbi.nlm.nih.gov/articles/PMC9213584/
Epigenetic ageing clocks: statistical methods and emerging computational challenges
https://www.nature.com/articles/s41576-024-00807-w
DNA methylation of the ELOVL2, FHL2, KLF14, C1orf132/MIR29B2C, and TRIM59 genes for age prediction from blood, saliva, and buccal swab samples
https://www.fsigenetics.com/article/S1872-4973(18)30238-2/abstract
Methylclock – DNA methylation-based clocks
https://www.bioconductor.org/packages/release/bioc/html/methylclock.html
methylclock software pkg
https://isglobal-brge.github.io/methylclock/index.html
“methylclock package allows to estimate chronological and gestational DNA methylation (DNAm) age as well as biological age using different methylation clocks. The package includes the following estimators…”
(tech specs on a *lot* of clocks)
Oxygen cocktail
Oxygen cocktail: clarify this is *not* a medical treatment, address misinformation.
Anti-inflammatory
Anti-inflammatory (and redirects). Change title? Edit section headings for each drug classes to higher level to allow subsections as needed. New article for “anti-inflammatory diet”? Add to “further reading” section & include non-drug approaches for treating acute & chronic inflammation, other inflammatory proceses.
Parmacodynamics
Pharmacodynamics. Cleanup biophysics terms (definitions, methods), add citations.
Sandbox
User:BetsyRogers/sandbox
https://en.wikipedia.org/wiki/Wikipedia:Sandbox
https://en.wikipedia.org/wiki/Wikipedia:Sandbox
https://en.wikipedia.org/wiki/Wikipedia:About_the_sandbox
https://en.wikipedia.org/wiki/Help:My_sandbox
Templates
More citations needed (article):
Unreferenced medical section
Unreliable medical source (no box)
[unreliable medical source?]
Disputed
