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The C5orf15 gene is thought to be an integral component of the membrane. It is predicted to be located in the [[golgi apparatus]]<ref>{{Cite web |title=Subcellular – C5orf15 – The Human Protein Atlas |url=https://www.proteinatlas.org/ENSG00000113583-C5orf15/subcellular |access-date=2025-09-20 |website=www.proteinatlas.org}}</ref>. |
The C5orf15 gene is thought to be an integral component of the membrane. It is predicted to be located in the [[golgi apparatus]]<ref>{{Cite web |title=Subcellular – C5orf15 – The Human Protein Atlas |url=https://www.proteinatlas.org/ENSG00000113583-C5orf15/subcellular |access-date=2025-09-20 |website=www.proteinatlas.org}}</ref>. |
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=== Aliases<ref>{{Cite web |title=C5orf15 chromosome 5 open reading frame 15 [Homo sapiens (human)] – Gene – NCBI |url=https://www.ncbi.nlm.nih.gov/gene/56951 |access-date=2025-09-20 |website=www.ncbi.nlm.nih.gov}}</ref>: === |
=== Aliases<ref>{{Cite web |title=C5orf15 chromosome 5 open reading frame 15 [Homo sapiens (human)] – Gene – NCBI |url=https://www.ncbi.nlm.nih.gov/gene/56951 |access-date=2025-09-20 |website=www.ncbi.nlm.nih.gov}}</ref>: === |
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* KCT2 |
* KCT2 |
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* HTGN29 |
* HTGN29 |
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== Evolution: == |
== Evolution: == |
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The C5orf15 protein has orthologs that can be found in various mammals, birds, amphibians, reptiles, and fish<ref name=”:1″ />. The C5orf15 protein (keratinocyte-associated transmembrane protein 2) has orthologs dating back to sea lampreys (Table 1). The protein sequence is highly conserved (>50% identity) until monotremes are reached evolutionarily<ref name=”:4″ />. There is a variety of primates the C5orf15 protein ortholog is found in, as well as all mammals looked at. Orthologs were present in the classifications of mammalia, aves, reptilia, amphibia, and bony, cartilaginous, and jawless fish. No orthologs were found beyond this. |
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The C5orf15 gene has orthologs that can be found in various mammals, birds, amphibians, reptiles, and fish<ref name=”:1″ />. Pair-Wise Assessment tools showed conservation of the C-terminus of the C5orf15 protein in ”[[Human|Homo Sapiens]], [[Chicken|Gallus Gallus]],” and ”[[Western clawed frog|Xenopus tropicalis]]”<ref>{{Cite web |url=https://www.ebi.ac.uk/jdispatcher/psa/emboss_needle/summary?jobId=emboss_needle-I20250916-220340-0438-96009726-p1m |access-date=2025-09-20 |website=www.ebi.ac.uk}}</ref>”[[Western clawed frog|.]]” ” ” |
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[[File:Paralogs Spreadsheet.png|thumb|921x921px|Human C5orf15 Protein and Orthologs Found in 21 Species, including mammalia, aves, reptilia, amphibia, and bony, cartilaginous, and jawless fish. ]] |
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== Transcript: == |
== Transcript: == |
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Revision as of 03:20, 10 October 2025
C5orf15 Gene Information
Keratinocyte-associated transmembrane protein 2 is a Single-pass membrane protein[1] which, in humans, is encoded by the C5orf15 gene. The gene is located on chromosome 5, specifically at 5q31.1 on the negative strand. C5orf15 spans 2188 base pairs from 133,304,478 to 133,291,199, which includes three exons[2]. The C5orf15 gene has one protein-coding sequence (Ref: NC_000005.10).
The C5orf15 gene is thought to be an integral component of the membrane. It is predicted to be located in the golgi apparatus[3].
- KCT2
- HTGN29
- chromosome 5 open reading frame 15
| mRNA Accession Number | Nucleotide Accession Number | Gene ID | mRNA Length |
|---|---|---|---|
| NM_020199.3 | NC_000005.10 | 56951 | 13,116 nt
2188 bp |
C5orf15 Protein Information:
The C5orf15 mRNA codes for a 265 amino acid protein, with one isoform[5]. The function of the C5orf15 protein is not yet well understood in the scientific community. The C5orf15 protein contains regions of phosphorylation, glycosylation, a transmembrane region, and two disordered regions[5]. It is shown to have 36 interactions with physical evidence and one with genetic evidence. Some of the interactions include ORF7B, C4BPA, E, and IL20RB[6].
| Protein Accession Number | Protein Name | Protein Length | Molecular Weight |
| NP_064584.1 | keratinocyte-associated transmembrane protein 2 precursor | 265 aa | ~29 kDa |
Expression:
The C5orf15 protein is found in most cell and tissue types within the human body[1]. High expression was seen in the tissues and cells of the thyroid gland, stomach, small intestine, duodenum, colon, gallbladder, pancreas, placenta, bone marrow, and endometrium[7]. A low expression is observed in spleen, salivary gland, and soft tissue . No expression of C5orf15 has been observed in adipose tissue. Expression has been classified under Cluster 1 Liver and Kidney-Metabolism[7].
Evolution:
The C5orf15 protein has orthologs that can be found in various mammals, birds, amphibians, reptiles, and fish[2]. The C5orf15 protein (keratinocyte-associated transmembrane protein 2) has orthologs dating back to sea lampreys (Table 1). The protein sequence is highly conserved (>50% identity) until monotremes are reached evolutionarily[4]. There is a variety of primates the C5orf15 protein ortholog is found in, as well as all mammals looked at. Orthologs were present in the classifications of mammalia, aves, reptilia, amphibia, and bony, cartilaginous, and jawless fish. No orthologs were found beyond this.
Transcript:
