Draft:Joaquim Roca: Difference between revisions

 

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{{Infobox scientist

{{Infobox scientist

| name = Joaquim Roca

| name = Joaquim Roca

| image = File:Joaquim Roca 2020.jpg

| image = File:Joaquim Roca .jpg

| image_size =

| image_size =

| alt =

| alt =

| caption = Roca in 2020

| caption = Roca in

| birth_name = Joaquim Roca Bosch

| birth_name = Joaquim Roca Bosch

| birth_date = 1960

| birth_date = 1960

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File:Joaquim Roca 2020.jpg (Image)

https://orcid.org/0000-0003-1462-954X

https://orcid.org/0000-0003-1462-954X

https://scholar.google.com/citations?user=096bK34AAAAJ&hl=en

https://scholar.google.com/citations?user=096bK34AAAAJ&hl=en

https://www.researchgate.net/profile/Joaquim-Roca

https://www.researchgate.net/profile/Joaquim-Roca

https://www.scopus.com/authid/detail.uri?authorId=7101624422

https://www.scopus.com/authid/detail.uri?authorId=7101624422

https://www.webofscience.com/wos/author/record/75563400

https://www.webofscience.com/wos/author/record/75563400

https://www.semanticscholar.org/author/Joaquim-Roca/144659853?sort=pub-date

https://www.semanticscholar.org/author/Joaquim-Roca/144659853?sort=pub-date

https://www.csic.es/en/investigation/research-groups/joaquim-roca-dna-topology-lab

https://www.csic.es/en/investigation/research-groups/joaquim-roca-dna-topology-lab

https://digital.csic.es/cris/rp/rp11063

https://digital.csic.es/cris/rp/rp11063

https://scholia.toolforge.org/author/Q42324962

https://scholia.toolforge.org/author/Q42324962

https://www.wikidata.org/wiki/Q42324962

https://www.wikidata.org/wiki/Q42324962

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https://viaf.org/en/viaf/WKP%7CQ42324962

https://viaf.org/en/viaf/WKP%7CQ42324962

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Spanish scientist

Joaquim Roca is a Spanish biomedical scientist internationally renowned for his research on Chromosome DNA topology. He is a Professor at the Spanish National Research Council (CSIC)[1] and currently leads the DNA Topology Lab at the Institute of Molecular Biology of Barcelona (IBMB)[2][3].

Roca received his medical degree (MD) in 1984 from the University of Barcelona, his master degree (MS) in 1995 from the Polytechnic University of Catalonia, and his doctorate (PhD) in 1988 from the University of Barcelona.[4]
[5]
[6]. His doctoral thesis on DNA topoisomerase activities during the spermatogenesis received the University of Barcelona extraordinary award for doctoral studies [7] [8]
[9]

In 1988, after serving one year as Assistant professor of Physiology at the Faculty of Medicine in Barcelona[10], Roca moved to Harvard University to work as a Postdoctoral Fellow (1988-1991) and later as a Research Associate (1992-1995) in the laboratory of James C. Wang. In 1996, he obtained an academic tenure position at the Spanish National Research Council (CSIC)[11] and returned to Barcelona to establish the DNA Topology Laboratory at IBMB[12][13]. Roca was promoted to research Professor in 2008. He served as Chairman of the Department of Molecular and Cellular Biology (2002-2006), as Deputy Director of IBMB (2006-2010), and as Chairman of the Department of Structural and Molecular Biology (2023-2026) [14][15][16][17].

Roca’s work focuses on the nanomechanics of chromosome DNA topology, exploring how the twisting and coiling of DNA are regulated, and how these parameters determine the conformation and the three-dimensional path of DNA during genome activities. A main challenge in this field is the scarcity of specialists and the limited availability of technical approaches to assess the conformation of the DNA double helix within cells. Roca’s research has led to key discoveries and methodological advances
[18]
[19]
[20]
[21]
, including:

• The discovery of intracellular DNA knots and their interplay with genome activities.^[11][12][13]

• The design of new methods for genome-wide mapping of the un-constrained topolome (DNA helical tension)^[16][17] and the the constrained topolome (DNA deformations stabilised by chromatin elements).^[18]