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Later, he served as vice president at [[aTyr Pharma]] in [[San Diego]],<ref name=”picibio” /> before joining the [[Parker Institute for Cancer Immunotherapy]] in [[San Francisco]], where he was chief scientific officer.<ref name=”uclanewsroom” /> |
Later, he served as vice president at [[aTyr Pharma]] in [[San Diego]],<ref name=”picibio” /> before joining the [[Parker Institute for Cancer Immunotherapy]] in [[San Francisco]], where he was chief scientific officer.<ref name=”uclanewsroom” /> |
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held the role of chief scientific officer.<ref>{{cite web |last=Pashricha |first=Akash |date=6 August 2021 |title=A life sciences startup will base its headquarters in both Seattle and California. It’s far from the only one |url=https://www.seattletimes.com/business/local-business/a-life-sciences-startup-will-base-its-headquarters-in-both-seattle-and-california-its-far-from-the-only-one/ |access-date=6 October 2025 |website=[[The Seattle Times]]}}</ref> |
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== Honors and awards == |
== Honors and awards == |
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Revision as of 13:24, 8 October 2025
American immunologist (born 1960)
Frederick Jay Ramsdell[1] (born December 4, 1960)[2] is an American immunologist working at Sonoma Biotherapeutics in San Francisco, California.[2]
In 2025, he was jointly awarded the Nobel Prize in Physiology or Medicine for his work in peripheral tolerance.[3]
Education and career
Ramsdell was born on December 4, 1960 in Elmhurst, Illinois.[2]
He received a Bachelor of Science degree with a major in biochemistry and cell biology from the University of California, San Diego in 1983.[4] In the same year, he enrolled at the University of California, Los Angeles as a doctoral student, and studied microbiology and immunology under the mentorship of Sidney Golub, receiving his Doctor of Philosophy degree in 1987.[5]
After earning his PhD, Ramsdell served a fellowship at the National Institutes of Health. After that, he joined the biopharmaceutical company Immunex, where his main research focus was T cell activation and tolerance and gene discovery.[5][6] In 1994, he joined the Bothell, Washington-based biotechnology company Darwin Molecular (along with Mary E. Brunkow), where he established an immunology program. Darwin Molecular was acquired by Chiroscience in 1996. Three years later, Chiroscience merged with Celltech (briefly under the name Celltech Chiroscience). In 2004, Ramsdell and Brunkow left the company.[5][7]
He joined ZymoGenetics in 2004 where he led research teams focusing on novel proteins with potential regulatory activity in lymphoid cells.[8] In 2008, he started working at Novo Nordisk where he helped establish the firm’s Inflammation Research Center in Seattle and became leader of the immunobiology group.[8][6]
Later, he served as vice president at aTyr Pharma in San Diego,[8] before joining the Parker Institute for Cancer Immunotherapy in San Francisco, where he was chief scientific officer.[5]
In 2019, he co-founded Sonoma Biotherapeutics with Jeffrey Bluestone, Qizhi Tang and Alexander Rudensky,[9] where he previously held the role of chief scientific officer.[10] As of 2025, he is the chair of the company’s scientific advisory board.[11]
Honors and awards
In 2017, Ramsdell received, jointly with Shimon Sakaguchi and Alexander Rudensky, the Crafoord Prize for research in polyarthritis. He was cited for his “discovery of regulatory T cells that counteract damaging immune responses in arthritis and other autoimmune diseases”.[12][13]
Ramsdell was jointly awarded, with Sakaguchi and Mary E. Brunkow, the 2025 Nobel Prize in Physiology or Medicine.[3] On the day of the announcement, he was unable to be contacted to receive his prize as he was hiking off-the-grid in Idaho.[14] Ramsdell later told the BBC that his first response when he did learn the news from his wife was “I did not!”, to which she replied that she had 200 text messages suggesting otherwise.[15]
References
- ^ a b “Generation of lymphokine-activated killer cells from non-natural killer cell sources: Development from human thymocytes”. ProQuest. Retrieved October 6, 2025.
- ^ a b c “Nobel Prize in Physiology or Medicine 2025: Fred Ramsdell”. NobelPrize.org. Retrieved October 6, 2025.
- ^ a b “Nobel Prize in Physiology or Medicine 2025 Summary”. NobelPrize.org. Retrieved October 6, 2025.
- ^ “UC San Diego Alumnus Wins Nobel Prize in Physiology or Medicine”. UC San Diego Today. University of California, San Diego. October 6, 2025. Retrieved October 8, 2025.
- ^ a b c d Schindler, Todd; Gondo, Nancy (October 6, 2025). “UCLA alumnus Fred Ramsdell wins 2025 Nobel Prize in physiology or medicine”. UCLA Newsroom. University of California, Los Angeles. Retrieved October 8, 2025.
- ^ a b Harrington, Adam; McMillan, Natalie (October 6, 2025). “Scientist originally from Elmhurst, Illinois wins Nobel Prize in medicine”. CBS News Chicago. Retrieved October 8, 2025.
- ^ Stiffler, Lisa (October 7, 2025). “How a scrappy biotech startup backed by Microsoft’s co-founders set the stage for two Nobel winners”. GeekWire. Retrieved October 8, 2025.
- ^ a b c “About Fred Ramsdell, PhD – Chief Scientific Officer” (PDF). Parker Institute for Cancer Immunotherapy. Retrieved October 8, 2025.
- ^ Eisenstein, Michael (June 16, 2021). “Sonoma Biotherapeutics: rallying the regulators”. Nature Biotechnology. doi:10.1038/d41587-021-00008-4. Retrieved October 8, 2025.
- ^ Pashricha, Akash (August 6, 2021). “A life sciences startup will base its headquarters in both Seattle and California. It’s far from the only one”. The Seattle Times. Retrieved October 6, 2025.
- ^ “Sonoma Biotherapeutics Congratulates Fred Ramsdell, PhD, Co-Founder and Scientific Advisory Board Chair, on Receiving the 2025 Nobel Prize in Physiology or Medicine for his work in Immunotherapy and Breakthrough Understanding of the Role of Regulatory T cells (Tregs)”. Sonoma Biotherapeutics. October 6, 2025. Retrieved October 8, 2025.
- ^ “The Crafoord Prize in Polyarthritis 2017”. CrafoordPrize.se. Archived from the original on January 12, 2017. Retrieved April 6, 2019.
- ^ “Sakaguchi, Ramsdell, Rudensky win Crafoord Prize for discoveries in immune regulation”. CancerLetter.com. January 13, 2017. Retrieved October 6, 2025.
- ^ France-Presse, Agence (October 6, 2025). “Nobel committee unable to reach prize winner who is ‘living his best life’ hiking off grid”. The Guardian. ISSN 0261-3077. Retrieved October 7, 2025.
- ^ Chater, James (October 8, 2025). “Scientist’s off-grid hike interrupted by news of Nobel Prize win”. BBC News. Retrieved October 8, 2025.
External links
