User:Schm6041/PXDC1: Difference between revisions - Wikipedia

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=== Common Aliases ===

PXDC1 is also known as c6orf145.<ref name=”:0″ /> ~~should show up in gene box, if so can remove.~~

PXDC1 is also known as c6orf145.<ref name=”:0″ />

=== Number of Exons ===

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=== Span of Gene ===

The gene is found on [[chromosome 6]] (6p25.2) in the minus strand and the resulting mRNA has 8 exons, with 5 of them in the coding sequence. It is the longest transcript at 1,878 bp and encodes the longest [[Protein isoform|isoform]] PXDC1 which is 231 amino acids long.<ref name=”:1″ /> The mass of the protein is ~27 kDa and it has a pI of 4.67. Its 3D structure can be seen in Figure 1. It is predicted to be involved in enabling [[phosphatidylinositol]] binding activity and it is expressed in 26 tissues.

should be in gene box?

== mRNA ==

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=== Conceptual Translation ===

[[File:~~Conceptual~~ ~~translation1~~.png|left|thumb|~~463x463px~~|Part 1 of conceptual translation of human PXDC1.]]

[[File: .png|left|thumb||Part 1 of conceptual translation of human PXDC1.]]

⚫

[[File: transl.png|thumb||Part 2 and key of conceptual translation of human PXDC1.]]

⚫

[[File:~~Part2 conc~~ transl.png|thumb|~~415x415px~~|Part 2 and key of conceptual translation of human PXDC1. ~~|none~~]]

== Protein ==

=== Known Isoforms ===

Transcript variants are shown in previous mRNA heading. These encode two isoforms:

* PXDC1 isoform 1: 231 amino acids

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=== MW, pI, Amino Acid Composition ===

The mass of the protein is ~27 kDa and it has a pI of 4.67.<ref>{{Cite web |title=PXDC1 Gene |url=https://www.genecards.org/cgi-bin/carddisp.pl?gene=PXDC1 |access-date=2025-09-19 |website=GeneCards}}</ref><ref>{{Cite web |title=Ensembl Genome Browser |url=https://grch37.ensembl.org/index.html |access-date=2025-10-20 |website=grch37.ensembl.org}}</ref> The composition of amino acids is comparable to that of a typical human protein, however the difference between the number of lysine and arginine residues compared to that of glutamate and aspartate is negative compared to the average human protein.<ref>{{Cite web |last=EMBL-EBI |last2=Institute |first2=European Bioinformatics |title=Job Dispatcher homepage {{!}} EMBL-EBI |url=https://www.ebi.ac.uk/jdispatcher/ |access-date=2025-12-04 |website=www.ebi.ac.uk |language=en}}</ref> This is consistent with the observed pI, which indicates acidity.

Molecular weight of the protein is 26,560 Da.<ref>{{Cite web |title=PXDC1 Gene |url=https://www.genecards.org/cgi-bin/carddisp.pl?gene=PXDC1 |access-date=2025-09-19 |website=GeneCards}}</ref>

⚫

=== Domains and Motifs ===

pI is 4.67.<ref>{{Cite web |title=Ensembl Genome Browser |url=https://grch37.ensembl.org/index.html |access-date=2025-10-20 |website=grch37.ensembl.org}}</ref>

⚫

[[File: .png|thumb||Protein diagram for human PXDC1 highlighting domains, exon boundaries, and predicted post-translational modifications.IBS 2.0: an upgraded illustrator for the visualization of biological sequences. ”Nucleic Acids Research”, 2022. DOI: 10.1093/nar/gkac373.]]

[[File:Compositional analysis of pxdc1.png|thumb|592x592px|Compositional analysis of human PXDC1 protein.<ref>{{Cite web |last=EMBL-EBI |last2=Institute |first2=European Bioinformatics |title=Job Dispatcher homepage {{!}} EMBL-EBI |url=https://www.ebi.ac.uk/jdispatcher/ |access-date=2025-12-04 |website=www.ebi.ac.uk |language=en}}</ref>|none]]

⚫

=== Domains and Motifs ===

⚫

[[File:~~Pxdc1~~ ~~protein cartoon~~.png|thumb|~~492x492px~~|Protein diagram for human PXDC1 highlighting domains, exon boundaries, and predicted post-translational modifications.IBS 2.0: an upgraded illustrator for the visualization of biological sequences. ”Nucleic Acids Research”, 2022. DOI: 10.1093/nar/gkac373.~~|none~~]]

=== Post-Translational Modifications ===

{| class=”wikitable mw-collapsible”

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Phosphorylation sites in PXDC1 protein.<ref>Sequence- and structure-based prediction of eukaryotic protein phosphorylation sites. ”Blom, N., Gammeltoft, S., and Brunak, S.” Journal of Molecular Biology: 294(5): 1351-1362, 1999.</ref>

Residue S147 is also predicted to be O-GalNAc (mucin type) glycosylated.<ref>”’Precision mapping of the human O-GalNAc glycoproteome through SimpleCell technology.”’

⚫

=== ~~Secondary~~ Structure ===

[[File:2nd structure part1.png|thumb|501x501px|Part 1 of conceptual translation to highlight secondary structure in human PXDC1.<ref>ITASSER server <nowiki>[https://aideepmed.com/I-TASSER/]</nowiki>.</ref>|none]][[File:Part 2 secondary structure.png|thumb|495x495px|Part 2 of conceptual translation to highlight secondary structure in human PXDC1.<ref>ITASSER server <nowiki>[https://aideepmed.com/I-TASSER/]</nowiki>.</ref>|none]]

”Steentoft C, Vakhrushev SY, Joshi HJ, Kong Y, Vester-Christensen MB, Schjoldager KT, Lavrsen K, Dabelsteen S, Pedersen NB, Marcos-Silva L, Gupta R, Bennett EP, Mandel U, Brunak S, Wandall HH, Levery SB, Clausen H.”

[[File:Key conceptual translation.png|thumb|423x423px|Key for conceptual translation.|none]]

=== Tertiary Structure ===

”’EMBO J”’, 32(10):1478-88, May 15, ”’2013”’.

⚫

[[File:3 structure pxdc1.png|thumb|488x488px|Predicted tertiary structure of PXDC1 human protein. Coloring is red for N terminus and purple for C terminus with progression through rainbow colors.ITASSER server [https://aideepmed.com/I-TASSER/].{{Cite web |title=iCn3D: Web-based 3D Structure Viewer |url=https://www.ncbi.nlm.nih.gov/Structure/icn3d/full.html |access-date=2025-12-04 |website=www.ncbi.nlm.nih.gov}}|none]]

(doi: 10.1038/emboj.2013.79. Epub 2013 Apr 12)</ref>

⚫ ⚫

=== Subcellular Localization ===

Localized to the cytosolic face of the plasma membrane, and is associated peripherally.<ref>PSORT II Server <nowiki>[https://psort.hgc.jp/cgi-bin/runpsort.pl]</nowiki>.</ref><ref>{{Cite web |title=PXDC1 protein expression summary – The Human Protein Atlas |url=https://www.proteinatlas.org/ENSG00000168994-PXDC1 |access-date=2025-12-04 |website=www.proteinatlas.org}}</ref>

=== Protein Interactions ===

section and table.

{| class=”wikitable”

| valign=”top” |”’Interactor”’

| valign=”top” |Interactor

| valign=”top” |~~”’Confidence”’~~

| valign=”top” |

⚫

| valign=”top” |

|Score

| valign=”top” |LIN7C

| valign=”top” |~~0.53~~

| valign=”top” |

| valign=”top” |Plays a role in establishing/maintaining the asymmetric distribution of channels/receptors at the plasma membrane of polarized cells.

⚫

| valign=”top” |~~APBA1~~

| valign=”top” |

| valign=”top” |~~0.35~~

| valign=”top” |

| valign=”top” |GTP-hydrolysis activating protein (GAP) for small GTPase RAB22A. Plays a role in endocytosis and intracellular protein transport.

⚫

| valign=”top” |~~CASK~~

| valign=”top” |

| valign=”top” |~~0.35~~

| valign=”top” |

| valign=”top” |Plays a role in establishing/maintaining the asymmetric distribution of channels/receptors at the plasma membrane of polarized cells.

| valign=”top” |~~LIN7A~~

| valign=”top” |

⚫

| valign=”top” |LIN7B

⚫

| valign=”top” |RABGAP1L

⚫

~~Results~~ ~~from~~ ~~IMEx~~ ~~and~~ ~~IntAct~~ ~~protein~~ ~~interaction searches~~ with ~~human~~ PXDC1.<ref>EMBL-EBI IMEx <nowiki>[https://www.ebi.ac.uk/intact/imex/home.xhtml]</nowiki>.</ref><ref>{{Cite web |title=IntAct Portal |url=https://www.ebi.ac.uk/intact/home |access-date=2025-12-04 |website=www.ebi.ac.uk}}</ref>

with PXDC1.<ref>EMBL-EBI IMEx <nowiki>[https://www.ebi.ac.uk/intact/imex/home.xhtml]</nowiki>.</ref><ref>{{Cite web |title=IntAct Portal |url=https://www.ebi.ac.uk/intact/home |access-date=2025-12-04 |website=www.ebi.ac.uk}}</ref>

== Homology ==

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==== Evolution Speed ====

PXDC1 has a slow evolution rate compared to that of the fibrinogen alpha chain. It has a speed ~~more~~ similar to that of cytochrome c.<ref name=”:1″ /><ref>{{Cite web |last=EMBL-EBI |last2=Institute |first2=European Bioinformatics |title=Job Dispatcher homepage {{!}} EMBL-EBI |url=https://www.ebi.ac.uk/jdispatcher/ |access-date=2025-12-04 |website=www.ebi.ac.uk |language=en}}</ref>

PXDC1 has a slow evolution rate compared to that of the fibrinogen alpha chain. It has a speed similar to that of cytochrome c.<ref name=”:1″ /><ref>{{Cite web |last=EMBL-EBI |last2=Institute |first2=European Bioinformatics |title=Job Dispatcher homepage {{!}} EMBL-EBI |url=https://www.ebi.ac.uk/jdispatcher/ |access-date=2025-12-04 |website=www.ebi.ac.uk |language=en}}</ref>

[[File:Graphpxdc1evol.png|none|thumb|~~464x464px~~|Graph of relative evolution of PXDC1 compared to that of cytochrome c and the fibrinogen alpha chain. All 20 orthologs were used to construct the PXDC1 line~~. 5 organisms that were already used had their corrected sequence divergence (m) calculated for the other proteins~~.]]

[[File:Graphpxdc1evol.png|none|thumb||Graph of relative evolution of PXDC1 compared to that of cytochrome c and the fibrinogen alpha chain. All 20 orthologs were used to construct the PXDC1 line.]]

=== Paralogs ===

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== Clinical Significance ==

say specific changes/associations (text-based PS1), do not say SNPs, only eQTLs if you have them

TCDD-sensitive mice had PXDC1 expression in the liver significantly repressed after exposure, PXDC1 may have a role in sensitivity to this toxin.<ref>{{Cite journal |last=Prokopec |first=Stephenie D. |last2=Lu |first2=Aileen |last3=Lee |first3=Sandy Che-Eun S. |last4=Yao |first4=Cindy Q. |last5=Sun |first5=Ren X. |last6=Watson |first6=John D. |last7=Soliymani |first7=Rabah |last8=de Borja |first8=Richard |last9=Wong |first9=Ada |last10=Sam |first10=Michelle |last11=Zuzarte |first11=Philip |last12=McPherson |first12=John D. |last13=Okey |first13=Allan B. |last14=Pohjanvirta |first14=Raimo |last15=Boutros |first15=Paul C. |date=2019-10-01 |title=Comparative toxicoproteogenomics of mouse and rat liver identifies TCDD-resistance genes |url=https://doi.org/10.1007/s00204-019-02560-0 |journal=Archives of Toxicology |language=en |volume=93 |issue=10 |pages=2961–2978 |doi=10.1007/s00204-019-02560-0 |issn=1432-0738}}</ref>

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Predicted tertiary structure of PXDC1 human protein. Coloring is red for N terminus and purple for C terminus with progression through rainbow colors.^[5]^[6]

The PX (Phox homology) domain-containing 1, also known as PXDC1 and C6orf145, is a protein which in humans is encoded by the protein coding gene PXDC1 which is 29,095 bp long. The gene is found on chromosome 6 (6p25.2) in the minus strand and the resulting mRNA has 8 exons, with 5 of them in the coding sequence. It is the longest transcript at 1,878 bp and encodes the longest isoform PXDC1 which is 231 amino acids long.^[7] The mass of the protein is ~27 kDa and it has a pI of 4.67. Its 3D structure can be seen in Figure 1. It is predicted to be involved in enabling phosphatidylinositol binding activity and it is expressed in 26 tissues. The areas with the highest expression include the liver, placenta, and the gall bladder.^[8] Add key info here!! fix headings.

Gene

Common Aliases

PXDC1 is also known as c6orf145.^[8]

Number of Exons

Human protein contains 8 exons, with 5 of them in the coding sequence.^[7]

Span of Gene

The gene is found on chromosome 6 (6p25.2) in the minus strand and the resulting mRNA has 8 exons, with 5 of them in the coding sequence. It is the longest transcript at 1,878 bp and encodes the longest isoform PXDC1 which is 231 amino acids long.^[7] The mass of the protein is ~27 kDa and it has a pI of 4.67. Its 3D structure can be seen in Figure 1. It is predicted to be involved in enabling phosphatidylinositol binding activity and it is expressed in 26 tissues.

mRNA

Transcript Variants

Transcript variant	Accession #	Length (nt)	Exons	Protein isoform	Accession #	Length (aa)	Molecular Weight (kDa)
Variant 1	NM_183373.4	1878	1-5	1	NP_899229.2	231	231
Variant X2	XM_011514393.4	1718	2-5	X1	XP_011512695.1	170	170

Transcript variants of PXDC1 gene.^[7]^[9]^[10]

Expression Pattern

Expression is ubiquitous and variable across tissues. (add fold numbers).

Ubiquitous or tissue-specific?

High, moderate, low mRNA abundance

NCBI GEO profile across tissues, if really interesting

In situ hybridization data

Conceptual Translation

Protein

Known Isoforms

Transcript variants are shown in previous mRNA heading. These encode two isoforms:^[7]

PXDC1 isoform 1: 231 amino acids
PXDC1 isoform X1: 170 amino acids

MW, pI, Amino Acid Composition

The mass of the protein is ~27 kDa and it has a pI of 4.67.^[11]^[12] The composition of amino acids is comparable to that of a typical human protein, however the difference between the number of lysine and arginine residues compared to that of glutamate and aspartate is negative compared to the average human protein.^[13] This is consistent with the observed pI, which indicates acidity.

Domains and Motifs

Post-Translational Modifications

Location	Kinase	Full name
S3	cdc2	Cyclin-dependent kinase 1
T109	PKC	Protein Kinase C
S118	unsp	–
S130	unsp	–
S150	cdk5	Cyclin-dependent kinase 5
S176	unsp	–
S202	unsp	–
Y213	unsp	–
T215	PKG	Protein Kinase G
S218	DNAPK	DNA-dependent protein kinase
T227	CKII	Casein Kinase 2

Phosphorylation sites in PXDC1 protein.^[15]

Residue S147 is also predicted to be O-GalNAc (mucin type) glycosylated.^[16]

Structure

Subcellular Localization

Localized to the cytosolic face of the plasma membrane, and is associated peripherally.^[19]^[20]

Protein Interactions

Interactor	Full Name	Description	Score
LIN7C	Protein lin-7 homolog C	Plays a role in establishing/maintaining the asymmetric distribution of channels/receptors at the plasma membrane of polarized cells.	0.731
RABGAP1L	Rab GTPase-activating protein 1-like	GTP-hydrolysis activating protein (GAP) for small GTPase RAB22A. Plays a role in endocytosis and intracellular protein transport.	0.623
LIN7B	Protein lin-7 homolog B	Plays a role in establishing/maintaining the asymmetric distribution of channels/receptors at the plasma membrane of polarized cells.	0.610

Table 4. Common interactors that were found with PXDC1.^[21]^[22]^[23]^[24]

Homology

Orthologs

Class	Genus and Species	Common Name	Taxonomic Group	Median Date of Divergence from humans (MYA)	Accession #	Sequence Length (aa)	Identity (%)	Similarity (%)
Mammalia	Homo sapiens	Human	Primates	0	NP_899229.2	231	100	100
Mammalia	Mus musculus	Mouse	Rodents	87	NP_080107.3	231	92	94
Mammalia	Phascolarctos cinereus	Koala	Marsupials	160	XP_020829466.1	231	90	94
Mammalia	Notamacropus eugenii	Tammar wallaby	Marsupials	160	XP_072459796.1	231	89	94
Mammalia	Ornithorhynchus anatinus	Platypus	Monotremes	180	XP_001508393.1	231	87	92
Aves	Gallus gallus	Chicken	Fowl	319	XP_040520929.1	231	84	92
Reptilia	Pogona vitticeps	Central bearded dragon	Squamata	319	XP_020645452.1	231	86	92
Reptilia	Mauremys mutica	Yellowpond turtle	Turtles	319	XP_044863675.1	231	86	92
Amphibia	Ambystoma mexicanum	Axolotl	Salamanders	352	XP_069469606.1	231	86	92
Amphibia	Microcaecilia unicolor	Tiny cayenne caecilian	Caecilians	352	XP_030064485.1	230	85	92
Amphibia	Rhinatrema bivittatum	Two-lined caecilian	Caecilians	352	XP_029446414.1	230	85	91
Fish	Protopterus annectens	West African lungfish	Lobe-finned fish	408	XP_043937493.1	231	73	87
Fish	Acipenser oxyrinchus	Atlantic sturgeon	Ray-finned fish	429	KAK1173668.1	232	80	90
Fish	Seriola dumerili	Greater amberjack	Ray-finned fish	429	XP_022604539.1	233	73	86
Fish	Liparis tanakae	Tanaka’s snailfish	Ray-finned fish	429	TNN44386.1	230	73	86
Fish	Carcharodon carcharias	Great white shark	Sharks	462	XP_041039133.1	228	76	89
Fish	Pristiophorus japonicus	Japanese sawshark	Sawsharks	462	XP_070735904.1	228	76	88
Fish	Callorhinchus milii	Elephant shark	Chimaeras	462	XP_007900829.1	230	74	86
Fish	Leucoraja erinaceus	Little skate	Skates	462	XP_055509634.1	227	62	76
Fish	Myxine glutinosa	Atlantic hagfish	Hagfish	563	XP_067972370.1	263	36	48

Table of Orthologs to PXDC1.^[25]^[26]

Evolution Speed

PXDC1 has a slow evolution rate compared to that of the fibrinogen alpha chain. It has a speed similar to that of cytochrome c.^[7]^[27]

Graph of relative evolution of PXDC1 compared to that of cytochrome c and the fibrinogen alpha chain. All 20 orthologs were used to construct the PXDC1 line.

Paralogs

There are no direct paralogs of PXDC1, however, there are 49 proteins in humans that also contain the PX domain.^[28]

Clinical Significance

TCDD-sensitive mice had PXDC1 expression in the liver significantly repressed after exposure, PXDC1 may have a role in sensitivity to this toxin.^[29]

In the process of differentiation of dental pulp stem cells, PXDC1 was one of the genes whose expression was significantly altered. Suggests it may have a role in osteo/odontoblast differentiation.^[30]

Study showed that PXDC1 had a parent-of-origin expression bias, favored paternal allele. Also, less that 100 kB away from a known imprinted gene FAM50B.^[31]

Found that PXDC1 had a 2:1 paternal expression bias in lymphoblastoid cell lines and whole blood.^[32]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000168994 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021411 – Ensembl, May 2017
^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ITASSER server [https://aideepmed.com/I-TASSER/].
^ “iCn3D: Web-based 3D Structure Viewer”. www.ncbi.nlm.nih.gov. Retrieved 2025-12-04.
^ ^a ^b ^c ^d ^e ^f “NCBI Gene – PXDC1”. NCBI. Retrieved 2025-09-25.
^ ^a ^b “PXDC1 PX domain containing 1 [Homo sapiens (human)] – Gene – NCBI”. www.ncbi.nlm.nih.gov. Retrieved 2025-09-19.
^ “PX domain-containing protein 1 [Homo sapiens] – Protein – NCBI”. www.ncbi.nlm.nih.gov. Retrieved 2025-10-20.
^ “NCBI Nucleotide”.
^ “PXDC1 Gene”. GeneCards. Retrieved 2025-09-19.
^ “Ensembl Genome Browser”. grch37.ensembl.org. Retrieved 2025-10-20.
^ EMBL-EBI; Institute, European Bioinformatics. “Job Dispatcher homepage | EMBL-EBI”. www.ebi.ac.uk. Retrieved 2025-12-04.
^ IBS 2.0: an upgraded illustrator for the visualization of biological sequences. Nucleic Acids Research, 2022. DOI: 10.1093/nar/gkac373.
^ Sequence- and structure-based prediction of eukaryotic protein phosphorylation sites. Blom, N., Gammeltoft, S., and Brunak, S. Journal of Molecular Biology: 294(5): 1351-1362, 1999.
^ Precision mapping of the human O-GalNAc glycoproteome through SimpleCell technology.
Steentoft C, Vakhrushev SY, Joshi HJ, Kong Y, Vester-Christensen MB, Schjoldager KT, Lavrsen K, Dabelsteen S, Pedersen NB, Marcos-Silva L, Gupta R, Bennett EP, Mandel U, Brunak S, Wandall HH, Levery SB, Clausen H.

EMBO J, 32(10):1478-88, May 15, 2013.

(doi: 10.1038/emboj.2013.79. Epub 2013 Apr 12)
^ ITASSER server [https://aideepmed.com/I-TASSER/].
^ “iCn3D: Web-based 3D Structure Viewer”. www.ncbi.nlm.nih.gov. Retrieved 2025-12-04.
^ PSORT II Server [https://psort.hgc.jp/cgi-bin/runpsort.pl].
^ “PXDC1 protein expression summary – The Human Protein Atlas”. www.proteinatlas.org. Retrieved 2025-12-04.
^ EMBL-EBI IMEx [https://www.ebi.ac.uk/intact/imex/home.xhtml].
^ “IntAct Portal”. www.ebi.ac.uk. Retrieved 2025-12-04.
^ “BioGRID | Database of Protein, Chemical, and Genetic Interactions”. thebiogrid.org. Retrieved 2025-12-12.
^ “PXDC1 protein (human) – STRING interaction network”. string-db.org. Retrieved 2025-12-12.
^ “BLAST: Basic Local Alignment Search Tool”. blast.ncbi.nlm.nih.gov. Retrieved 2025-10-20.
^ “TimeTree :: The Timescale of Life”. timetree.org. Retrieved 2025-10-20.
^ EMBL-EBI; Institute, European Bioinformatics. “Job Dispatcher homepage | EMBL-EBI”. www.ebi.ac.uk. Retrieved 2025-12-04.
^ Chandra, Mintu; Collins, Brett M. (2019), Atassi, M. Zouhair (ed.), “The Phox Homology (PX) Domain”, Protein Reviews – Purinergic Receptors: Volume 20, Cham: Springer International Publishing, pp. 1–17, doi:10.1007/5584_2018_185, ISBN 978-3-030-14339-8, retrieved 2025-12-04
^ Prokopec, Stephenie D.; Lu, Aileen; Lee, Sandy Che-Eun S.; Yao, Cindy Q.; Sun, Ren X.; Watson, John D.; Soliymani, Rabah; de Borja, Richard; Wong, Ada; Sam, Michelle; Zuzarte, Philip; McPherson, John D.; Okey, Allan B.; Pohjanvirta, Raimo; Boutros, Paul C. (2019-10-01). “Comparative toxicoproteogenomics of mouse and rat liver identifies TCDD-resistance genes”. Archives of Toxicology. 93 (10): 2961–2978. doi:10.1007/s00204-019-02560-0. ISSN 1432-0738.
^ Liu, Zhongjun; Xu, Shuaimei; Dao, Junfeng; Gan, Zekun; Zeng, Xiongqun (2020-04). “Differential expression of lncRNA/miRNA/mRNA and their related functional networks during the osteogenic/odontogenic differentiation of dental pulp stem cells”. Journal of Cellular Physiology. 235 (4): 3350–3361. doi:10.1002/jcp.29223. ISSN 0021-9541.
^ Mozaffari, Sahar V.; Stein, Michelle M.; Magnaye, Kevin M.; Nicolae, Dan L.; Ober, Carole (2018-09-11). “Parent of origin gene expression in a founder population identifies two new candidate imprinted genes at known imprinted regions”. PLOS ONE. 13 (9): e0203906. doi:10.1371/journal.pone.0203906. ISSN 1932-6203. PMC 6133383. PMID 30204804.{{cite journal}}: CS1 maint: article number as page number (link) CS1 maint: unflagged free DOI (link)
^ GoNL Consortium; BIOS Consortium; Jadhav, Bharati; Monajemi, Ramin; Gagalova, Kristina K.; Ho, Daniel; Draisma, Harmen H. M.; van de Wiel, Mark A.; Franke, Lude; Heijmans, Bastiaan T.; van Meurs, Joyce; Jansen, Rick; ‘t Hoen, Peter A. C.; Sharp, Andrew J.; Kiełbasa, Szymon M. (2019-12). “RNA-Seq in 296 phased trios provides a high-resolution map of genomic imprinting”. BMC Biology. 17 (1). doi:10.1186/s12915-019-0674-0. ISSN 1741-7007. PMC 6589892. PMID 31234833. CS1 maint: unflagged free DOI (link)

User:Schm6041/PXDC1: Difference between revisions – Wikipedia